Al-Disi, D., Al-Daghri, N., Khanam, L., Al-Othman, A., Al-Saif, M., Sabico, S., & Chrousos, G. (2010) Subjective sleep duration and quality influence diet composition and circulating adipocytokines and ghrelin levels in teen-age girls. Endocrine Journal, 57(10), 915-23.

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Abstract

Understanding the interplay between sleep duration and quality, diet and hormones of obesity may help design effective lifestyle intervention strategies. Here we studied such associations in lean and obese teen-aged Saudi girls. In this cross-sectional observational study, 126 girls (62 lean and 64 obese) aged 14 -18 years (16.5 ± 1.5) were evaluated. A general questionnaire, which included sleep and diet questions, was obtained and anthropometric measurements and overnight fasting blood samples for determination of glucose, lipid profile and serum levels of leptin, adiponectin, resistin and ghrelin were collected. Subjects that slept < 5 hours/day had a higher percent of carbohydrate intake (p = 0.04) than those who slept > 7 hours/day. Adiponectin levels were higher in the lean than the obese group and increased in proportion to hours of sleep. Ghrelin had an inverse association with subjective sleep duration (p = 0.04), while resistin levels were directly proportional to it. Thus, the duration and quality of sleep influenced diet composition and the circulating levels of adipocytokines and ghrelin in adolescent girls. Long and uninterrupted sleep was associated with a better diet and a more favorable hormonal profile.

MeSH Terms
    Adipokines/blood*
    Adiponectin/blood
    Adolescent
    Body Mass Index
    Cross-Sectional Studies
    Diet*
    Energy Intake
    Female
    Ghrelin/blood*
    Humans
    Obesity/blood
    Obesity/physiopathology*
    Obesity/prevention & control
    Resistin/blood
    Saudi Arabia
    Sleep*
    Surveys and Questionnaires

Substances
    ADIPOQ protein, human
    Adipokines
    Adiponectin
    Ghrelin
    RETN protein, human
    Resistin