Matthews, K. A., Dahl, R. E., Owens, J. F., Lee, L., & Hall, M. (2012). Sleep duration and insulin resistance in healthy black and white adolescents. Sleep, 35(10), 1353-8.

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Abstract

Study Objectives

Poor sleep may play a role in insulin resistance and diabetes risk. Yet few studies of sleep and insulin resistance have focused on the important developmental period of adolescence. To address this gap, we examined the association of sleep and insulin resistance in healthy adolescents.

Design

Cross-sectional.

Setting

Community setting in one high school.

Participants

245 (137 African Americans, 116 males) high school students.

Measurements and Results

Participants provided a fasting blood draw and kept a sleep log and wore a wrist actigraph for one week during the school year. Participants' families were from low to middle class based on family Hollingshead scores. Total sleep time across the week averaged 7.4 h by diary and 6.4 h by actigraph; homeostatic model assessment of insulin resistance ([HOMA-IR] unadjusted) averaged 4.13. Linear regression analyses adjusted for age, race, gender, body mass index, and waist circumference showed that the shorter the sleep, the higher the HOMA-IR, primarily due to sleep duration during the week. No evidence was found for long sleep being associated with elevated HOMA-IR. Fragmented sleep was not associated with HOMA-IR but was associated with glucose levels.

Conclusions

Reduced sleep duration is associated with HOMA-IR in adolescence. Long sleep duration is not associated. Interventions to extend sleep duration may reduce diabetes risk in youth.

MeSH Terms
    Actigraphy
    Adolescent
    African Continental Ancestry Group*
    Blood Glucose/analysis
    Blood Glucose/physiology
    Cross-Sectional Studies
    European Continental Ancestry Group*
    Female
    Humans
    Insulin Resistance/physiology*
    Male
    Sleep/physiology*
    Sleep Deprivation/complications
    Sleep Deprivation/physiopathology
    Time Factors

Substances
    Blood Glucose